1.
Bioorg Chem
; 115: 105189, 2021 10.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34325218
RESUMO
The stereoselective cyclization of a C-16 acetylated 22,26-dioxocholestene derivative to give the spirostane E and F rings, under alkaline conditions, yields exclusively the (26R)-26-hydroxydiosgenin. Both experimental and computational data support the formation of a single diastereoisomer. The effect of diosgenin and (26R)-26-hydroxydiosgenin on rat ovary is also investigated.